This course is offered by the Department of Molecular Genetics of the VIB (Flanders Institute for Biotechnology)
Coordinator: Vincent Timmerman
Lecturers: Vincent Timmerman, N.
Goal and content
This course aims to provide a comprehensive overview on the molecular genetics and biology of peripheral neuropathies. The course starts with a clinical, electrophysiological and pathological survey of peripheral neuropathies. The following teaching classes are dedicated to the most recent molecular genetics and cell biology findings. Based on recent reviews and research papers we guide the student through the complex molecular architecture of the peripheral nerve, highlight the relevant functional pathways that maintain the peripheral nervous system. We will focus on the myelination process and on the interaction between the myelinating Schwann cells, the axon and the muscle. We discuss the pathomechanism of mutant proteins and make correlations between different neuropathy phenotypes in human and animal models. Sections are dedicated to the role of the immune system related to the pathomechanism of neurodegeneration and to therapeutic approaches.
Prerequisite knowledge: Relevant BA. A specific prerequisite for this course is knowledge of molecular genetics, gene and protein technologies, cell biology, neuroanatomy and neurophysiology
Teaching method: general introductions by instructors; student discussions about research papers and reviews.
Place/time/frequency: weekly classes over a twelve-week period.
Assessment: papers and presentations.
Literature: reader and handouts of the presentations, research papers and reviews.