|Course code module||2BBIC-021|
|Study load (hours)||196|
|Language of instruction:||Dutch|
|Semester exam information:||semester exam in January|
|Contract restriction information:|
Basic knowledge of chemistry, biology, mathematics and physics
Structure of biopolymers
Students wishing to include this course in their Individualised Learning Path should have acquired credits for the following courses (or these courses should be part of a study programme for which the student has passed):
Chemistry I (1BBIC-08)
Chemistry II (1BBIC-09)
Organic Chemistry (1BCHE-05)
In addition, the following courses should also be included in the Individualised Learning Path:
2. Objectives (expected learning outcomes)
The student are expected to acquire insight into the general principles of enzymology, bioenergetics and the signal transduction process that regulates the metabolism.
3. Course content
The properties of enzymes are elucidated, as are the effects of enzyme, substrate, inhibitor and activator concentrations. Special attention is paid to the mechanisms that contribute to a quicker reaction of enzymes (proximity, orientation, forms of nucleophile and electrophile centres, acid-base catalysis…) as compared to a chemical reaction. Attention is also devoted to the structure of the active centre and to the mechanisms of substrate binding and catalysis on the basis of chymotrypsine. The regulation of enzymatic activity through allostery, cooperativeness, and covalent modifications is also discussed.
Besides dealing with the foundations of enzymology, the course provides an introduction in bioenergetics: how is energy transferred efficiently in the cell? An overview is provided of oxidative degradation of carbohydrates (glycolysis, citric acid cycle, oxidative phosphorylation).
The effect of hormones, growth factors, transcription factors and receptors, i.e. the signal transduction cascades, on the metabolism and on the enzymes discussed shall also be elucidated.
4. Teaching method
Direct contact: Lectures
5. Assessment method
Exam: Written, with oral presentation
6. Compulsory reading – study material
Lecture notes on Blackboard
7. Recommended reading - study material
Textbook: “Biochemistry” Berg, Tymoczko, Stryer (2003) .
- P.C. Engel, Enzymology-Labfax.