Hypoxia/oxidative stress. The effects of hypoxia and the role of hemeproetins herein will be studied in metabolic active tissues such as the brain. The neuroprotective role of neuro- and cytoglobin will be studied in vivo and in vitro using transgenesis (knock-out, overexpressing Mouse models and cellular systems) and differential proteomicanalyses in hypoxia and ischemic mouse models.
Study of the structur/function of globin based oxygensensors. The correct sensing of the oxygenconcentrationand its changes is of fundamental importance to the cell. We will study different globin based oxygensensors from different organisms (e.g. bacteria, C. elegans) with the goal to perceive a better understanding of this process in the eukaryotic cell.