Biochemistry of Domestic Animals II

Academic year: 2008-2009 Course code module 2BDIE-021 Semester: 1st semester Credits: 4 Study load (hours) 112 Theory (hours): 24,00 Practice/Exercises(hours): 20,00 Other (hours): Part-time program: 1 Instructor(s) Wim De Coen Dries Knapen Language of instruction: Dutch Semester exam information: exam in the 1st semester Contract restriction information: exam contract not possible 1. Prerequisites *Algemene competenties Thorough knowledge of the biochemical processes and pathways that are the subject of the course "Biochemistry of Domestic Animals I'. *Sequentiality 2. Objectives (expected learning outcomes) The final goal of the course "Biochemistry of Domestic Animals II" is to achieve a profound insight into the global energy metabolism. Furthermore, students will be able to apply this knowledge to specific case studies. This requires a thorough understanding of all common metabolic pathways. Therefore, this course starts with completing the overview of these pathways, since not all of them are being discussed in the course "Biochemistry of Domestic Animals I'. Furthermore, since different tissues are involved in global metabolism, it is important to cover hormone and neurotransmitter biochemistry as well. Students should therefore be able to: provide a detailed description of amino acid oxidation, the urea cycle, and lipid biosynthesis explain the molecular mechanism of the main signal transduction pathways apply their knowledge of signal transduction mechanisms to the sensory transduction in vision, olfaction and gustation describe chemotaxis and regulation of the cell cycle apply their knowledge of metabolic pathways to the specific properties and metabolic characteristics of different tissue types explain how differences among tissue types contribute to the regulation of the carbohydrate, lipid and protein metabolism, and of the global energy metabolism in general 3. Course content This course is subdivided into three parts: Completion of metabolic pathways overview. In this part, the overview of the most important mebabolic pathways, most of which have been discussed in "Biochemistry of Domestic Animals I", is completed. Amino acid oxidation and urea cycle Lipid biosynthesis Communication. This parts deals with the most important signal transduction pathwas (theory and illustrations). Furthermore, hormones and neurotransmitters are discussed (mode of action, receptors, biosynthesis, metabolisation, ...). Signal transduction - basic principles Signal transduction - examples Hormones Neurotransmitters Metabolism This part discusses global energy metabolism. First, specific properties of tissues that play a dominant role in energy metabolism are discussed (liver, adipose tissue, muscle, ...). Next, this information is integrated and interpreted together with the mechanisms on signal transduction studied previously to understand how the energy metabolism changes and is being regulated as a function of the energetic condition and demand of an organism. Tissue specific metabolism: liver Tissue specific metabolism: adipose tissue Tissue specific metabolism: other tissues Global energy metabolism Applications and examples 4. Teaching method Direct contact: Lectures Seminars (possible question and answer sessions) Practical sessions Personal work: Assignments - in group Portfolio 5. Assessment method Exam: Written, without oral presentation Closed book Multiple choice Open questions Practical exam Written assignment: Without oral presentation Portfolio: Without oral presentation 6. Compulsory reading – study material Printouts of course materials can be purchased, and are available for download through Blackboard. 7. Recommended reading - study material Lehninger 'Principles of Biochemistry' Metabolism at a glance 8. Tutoring The course instructor can always be reached through e-mail or Blackboard. During the academic year, additional lectures or seminars can be organised on student request to further elaborate on the course's content. laatste aanpassing: last update: 11/01/2009 15:44 dries.knapen