Project detail Title: Developing a global understanding of the PRC and NuRD complexes in stemm cell differentiation, in health and disease (4DCellfate). Duration: 01/12/2011 - 30/11/2016 Researcher(s): Principal investigator:  Sobott Frank Research Team(s): Biomolecular Mass Spectrometry Abstract: The goal of 4DCellFate is to understand how the PRC/NuRD complexes and their plethora of interactions (protein/protein, protein/nucleosome, protein/nucleic acids) regulate cell fate. The ultimate outcome of 4DCellFate will be to lay the foundations for understanding the role of the PRC/NuRD complexes in ES cell differentiation and cancer, specifically in leukaemogenesis.-