|Course code module||1MBMW-K-0222|
|Study load (hours)||168|
|Instructor(s)||Anne Marie Van Der Linden|
|Language of instruction:||English|
|Semester exam information:||exam in the 1st semester|
|Contract restriction information:||exam contract not possible|
Students should have basic knowledge of the structure and function of the human body in terms of anatomy, histology and physiology. More specific, the course assumes knowledge of the anatomy of the nervous system and the physiology of different cells of the CNS including the aspects of blood vessels integral in neurotransmission and neuroreceptors (see course Neuroscience Ba3) .
nowledge of the principles of different imaging techniques, b
asic mathematics and digital signal processing are required to understand the different image acquisitions and image reconstruction techniques.
In-vivo biomedical imaging techniques in pre-clinical and clinical context (1MBMW-K-0191)
2. Objectives (expected learning outcomes)
What are you considered to know/anticipate to have learnt by the end of this course?
you have developed a thorough knowledge of the newest imaging techniques and of their significance and application in imaging the central nervous system
You have developed an insight in the physical principles of different imaging techniques and their practical use in modern imaging instrumentation; you are able to describe these in your own words, recognize, formulate;
you have developed an insight in the reconstruction of different image modalities and the physical parameter which is being visualized (3D techniques, diffusion, perfusion, neural activity, macroscopic flow, angiography, contrast agents); you are able to describe these in your own words, recognize, formulate;
for each of the discussed imaging techniques you are able to describe the origin of the image intensities
both at the level of the acquisition parameters and the quantitative image processing
; you are able to explain why specific tissues are represented dark or bright in the images;
you have developed an insight on how different imaging techniques can be used in a preclinical and a clinical context
you know the different image modalities - and their principles - to visualize brain activity and can describe the complementarily among the techniques
you know which imaging techniques can support which aspect of brain research
you have a
thorough knowledge concerning the use of PET in preclinical and clinical neuro applications.
3. Course content
The course is considered as an integrated practical course in which the different techniques of neuroimaging are dealt with. The applications, indication and medical value of all techniques of neuroimaging will be discussed and illustrated by means of literature or practical examples. Appropriate levels of attention will be devoted to the advanced image processing used in biomedical research.
The course also gives insight in how image contrasts can be acquired (technically) and what are the underlying physiological or anatomical mechanisms for each image contrast.
In the introduction the anatomy/MRI/CT and existing neuroatlasses are compared between humans (clinical) and rodents (rat/mouse) (preclinical).
In the computer tomography (CT) section focus is made towards CT contrast agents and their applicability in preclinical and clinical context, perfusion CT, 3D techniques and CT-angiography.
In the magnetic resonance imaging (MRI) section focus is made towards MRI contrast agents and their applicability in both preclinical and clinical context, diffusion MRI and application of DW MRI in several applications (stroke, MS, development/degeneration white matter), perfusion weighted MRI with application of PW MRI in several applications (ischemia, brain tumors), MRI functional for brain functioning, flow and MR angiography with applications, ultrafast imaging with applications (use in fMRI, quantification volume brain regions), and leakage of blood-brain-barrier with dynamic MRI with use of contrast agents. Moreover both MR Spectroscopy and MR spectroscopic imaging is discussed, including their underlying principles and the neuro applications in preclinical and clinical context.
In the PET-MRI section the use of relevant tracers for neuro research in preclinical and clinical context is discussed. This technique however is more described in detail in the course ‘Molecular Imaging representation in preclinical and clinical’ context.
The students will be able to perform MR and CT experiments. The practical course is focused on the different MR techniques and the acquired physiological parameters (obtained using customized image processing techniques).
Day scheduled time location programmed lectures
Mon 26 Oct 09 8.30-12.30 G.U.2.44 Lecture 1: MRI-contrast principles
Lecture 2: Translat. anatomy: mice/rat-atlas
Tue 27 Oct 09 8.30-12.30 G.
Lecture 3: MR imaging principles
14.00-18.00 BIL Practice 1- group 1 & 2 (MR imaging general)
Wed 28 Oct 09 8.30-12.30 D.D-1.15 Lecture 4: MRI basic clinical and pre-clinical imaging
Lecture 5: Flow effects, flow imaging, angiography general)
Thu 29 Oct 09 8.30-12.30 BIL Practice 1- group 3 & 4 (MR imaging
14.00-18.00 D.U.2.44 Lecture 6: MRI-sequences
Fri 30 Oct 09 8.30-12.30 G.
Lecture 7: Diffusion and perfusion
14.00-18.00 BIL Practice 2- group 1 & 2 (MR diffusion imaging)
Tue 3 Nov 09 8.30-12.30 G.
Lecture 8: fMRI
14.00-18.00 BIL Practice 2- group 3 & 4 (MR diffusion imaging)
Wed 4 Nov 09 10.30-13.00 G.
Lecture 9: Contrast Agents &
14.00-18.00 BIL Practice 3- group 1 & 2 (fMRI)
Thu 5 Nov 09 10.30-12.30 D.D 0.23 Lecture 10: Clinical advanced MR (part paul parizel)
14.00-18.00 BIL Practice 3- group 3 & 4 (fMRI)
Fri 6 Nov 09 8.30-12.30 G.
Lecture 11: Compl. methods for Neuroimaging 13.30-15.45 BIL Practice 4- group 1 & 2 (perfusion)
15.45-18.00 BIL Practice 4- group 3 & 4 (perfusion)
Mon 9 Nov 09 17.00-21.00 D.D-1,23 Lecture 10: Advanced clinical MRI: Perfusion (J. Van Goethem) +
UZA Practice 5- group 1 & 2 (human MRI)
Tue 10 Nov 09 14.00-16.00 G.
Lecture 12: MRS
17.00-21.00 UZA Practice 5- group 3 & 4 (human MRI)
Thu 12 Nov 09 9.00-13.00 G.
Exam students "IP EMMI" ,
Only for UA-students, course Neuro-Imaging
Thu 12 Nov 09 17.00-21.00 D.D.-1.25 Lecture: advanced CT
Thu 19 Nov 09 17.00-21.00 UZA practicum CT
4. Teaching method
Direct contact: LecturesPractical sessions
5. Assessment method
Exam: Oral, with written preparationOpen questions
Continuous assessment: ExercisesAssignmentsParticipation in classroom activities
Written assignment: Without oral presentation
6. Compulsory reading – study material
Course document : Magnetic Resonance Imaging of the nervous system (Dr. M. Verhoye)
An electronic version of the presentations can be downloaded from Blackboard. A print out of the presentations (2 hand-out/page) can be bought at the reprography of the University of Antwerp.
7. Recommended reading - study material
Medical Imaging Physics, 4th ed. William R. Hendee, E. Russell Ritenour, ed. Wiley-Liss, 2002 , NY-ISBN 0-471-38226-4
Fundamentals of Medical Imaging, Paul Suetens
Publisher: Cambridge University Press; Bk&CD-Rom edition (March 2002)
MRI From picture to proton, Donald W. McRobbie, Elizabeth A. Moore, Martin J. Graves, Martin R. Prince,
Publisher: CambridgeUniversity Pres, ISBN 0-521-68384-X paperback
Radiobiology for the Radiologist, 6th ed. Eric J. Hall, Amato J. Giacca
Lippincott Williams & Wilkins, 2006, ISBN 0781741513
Medical Imaging, Signals and Systems, Jerry L. Prionce, Jonathan M. Links, Pearson Edudaction, ISBN 0-13-065353-5
You can always ask the teacher questions after or during the pause of a contact moment.
Beyond the contact moments, students are asked to contact the teacher in order to make an appointment.
Dr. Marleen Verhoye
University of Antwerp, Campus Groenenborger (CGB)
Tel: ++ 32 (0)3 2653389
++ 32 (0)3 2653230
Fax. ++ 32 (0)3 2653233