Personen | Personen nieuwe site | Google | Route | Contact Login 
Marleen Verhoye  
Course descriptions

Neuroimaging, preclinical and clinical studies
Academic year:2009-2010
Course code module1MBMW-K-0222
Semester:1st semester
Study load (hours)168
Theory (hours):35,00
Other (hours):5,00
Part-time program:1
Instructor(s)Anne Marie Van Der Linden
Marleen Verhoye
Paul Parizel
Language of instruction:English
Semester exam information:exam in the 1st semester
Contract restriction information:exam contract not possible

1. Prerequisites
*Algemene competenties

Students should have basic knowledge of the structure and function of the human body in terms of anatomy, histology and physiology.  More specific, the course assumes knowledge of the anatomy of the nervous system and the physiology of different cells of the CNS including the aspects of blood vessels integral in neurotransmission and neuroreceptors (see course Neuroscience Ba3) .

K nowledge of the principles of different imaging techniques, b asic mathematics and digital signal processing are required to understand the different image acquisitions and image reconstruction techniques.

In-vivo biomedical imaging techniques in pre-clinical and clinical context (1MBMW-K-0191)

2. Objectives (expected learning outcomes)

What are you considered to know/anticipate to have learnt by the end of this course?


  • you have developed a thorough knowledge of the newest imaging techniques and of their significance and application in imaging the central nervous system ;
  • You have developed an insight in the physical principles of different imaging techniques and their practical use in modern imaging instrumentation; you are able to  describe these in your own words, recognize, formulate;
  • you have developed an insight in the reconstruction of different image modalities and the physical parameter which is being visualized (3D techniques, diffusion, perfusion, neural activity, macroscopic flow, angiography, contrast agents); you are able to  describe these in your own words, recognize, formulate;
  • for each of the discussed imaging techniques you are able to  describe the origin of the image intensities both at the level of the acquisition parameters and the quantitative image processing ; you are able to explain why specific tissues are represented dark or bright in the images;
  • you have developed an insight on how different imaging techniques can be used in a preclinical and a clinical context
  • you know the different image modalities - and their principles - to visualize brain activity and can describe the complementarily among the techniques
  • you know which imaging techniques can support which aspect of brain research
  • you have a thorough knowledge concerning the use of PET in preclinical and clinical neuro applications.

3. Course content

The course is considered as an integrated practical course in which the different techniques of neuroimaging are dealt with. The applications, indication and medical value of all techniques of neuroimaging will be discussed and illustrated by means of literature or practical examples.  Appropriate levels of attention will be devoted to the advanced image processing used in biomedical research.     The course also gives insight in how image contrasts can be acquired (technically) and what are the underlying physiological or anatomical mechanisms for each image contrast.


In the introduction the anatomy/MRI/CT and existing neuroatlasses are compared between humans (clinical) and rodents (rat/mouse) (preclinical).


In the  computer tomography (CT) section focus is made towards CT contrast agents and their applicability in preclinical and clinical context, perfusion CT, 3D techniques and CT-angiography.


In the  magnetic resonance imaging (MRI) section focus is made towards MRI contrast agents and their applicability in both preclinical and  clinical context, diffusion MRI and application of DW MRI in several applications (stroke, MS,  development/degeneration white matter), perfusion weighted MRI with application of PW MRI in several applications (ischemia, brain tumors), MRI functional for brain functioning, flow and MR angiography with applications, ultrafast imaging with applications (use in fMRI, quantification volume brain regions), and leakage of blood-brain-barrier with dynamic MRI with use of contrast agents. Moreover both MR Spectroscopy and MR spectroscopic imaging is discussed, including their underlying principles and the neuro applications in preclinical and clinical context.

In the  PET-MRI section the use of relevant tracers for neuro research in preclinical and clinical context is discussed. This technique however is more described in detail in the course ‘Molecular Imaging representation in preclinical and clinical’ context.



The students will be able to perform MR and CT experiments.  The practical course is focused on the different MR techniques and the acquired physiological parameters (obtained using customized image processing techniques).


Day                         scheduled time           location           programmed lectures


Mon 26 Oct 09           8.30-12.30                 G.U.2.44         Lecture 1: MRI-contrast principles

                               14.00-18.00               G. U.2.44         Lecture 2: Translat. anatomy: mice/rat-atlas


 Tue 27 Oct 09          8.30-12.30                 G. U.2.44         Lecture 3: MR imaging principles

                               14.00-18.00               BIL                       Practice 1- group 1 & 2 (MR imaging general)


Wed 28 Oct 09          8.30-12.30                 D.D-1.15         Lecture 4: MRI basic clinical and pre-clinical imaging

                               14.00-18.00               G. U.2.44         Lecture 5: Flow effects, flow imaging, angiography           general)


Thu 29 Oct 09           8.30-12.30                 BIL                       Practice 1- group 3 & 4 (MR imaging

                               14.00-18.00               D.U.2.44         Lecture 6: MRI-sequences



Fri 30 Oct 09             8.30-12.30                 G. U.2.44         Lecture 7: Diffusion and perfusion

                               14.00-18.00               BIL                       Practice 2- group 1 & 2 (MR diffusion imaging)


Tue 3 Nov 09            8.30-12.30                 G. U.2.44         Lecture 8: fMRI

                               14.00-18.00               BIL                       Practice 2- group 3 & 4 (MR diffusion imaging)


Wed 4 Nov 09           10.30-13.00               G. U.2.44         Lecture 9: Contrast Agents  &

                               14.00-18.00               BIL                       Practice 3- group 1 & 2 (fMRI)


Thu 5 Nov 09            10.30-12.30               D.D 0.23         Lecture 10: Clinical advanced MR (part paul parizel)

                               14.00-18.00               BIL                       Practice 3- group 3 & 4 (fMRI)


Fri 6 Nov 09              8.30-12.30                 G. U.2.44         Lecture 11: Compl. methods for Neuroimaging     13.30-15.45       BIL                                     Practice 4- group 1 & 2 (perfusion)

                               15.45-18.00               BIL                       Practice 4- group 3 & 4 (perfusion)


Mon 9 Nov 09            17.00-21.00               D.D-1,23         Lecture 10: Advanced clinical MRI: Perfusion (J. Van                                                                Goethem) +

                                                               UZA                      Practice 5- group 1 & 2 (human MRI)


Tue 10 Nov 09          14.00-16.00               G. U.2.44         Lecture 12: MRS

                               17.00-21.00               UZA                      Practice 5- group 3 & 4 (human MRI)


Thu 12 Nov 09          9.00-13.00                 G. U.2.44/U241           Exam students "IP EMMI" ,


Only for UA-students, course Neuro-Imaging

Thu 12 Nov 09          17.00-21.00               D.D.-1.25        Lecture: advanced CT

Thu 19 Nov 09          17.00-21.00               UZA                practicum CT


4. Teaching method
Direct contact:
  • Lectures
  • Practical sessions

  • 5. Assessment method
  • Oral, with written preparation
  • Open questions

  • Continuous assessment:
  • Exercises
  • Assignments
  • Participation in classroom activities

  • Written assignment:
  • Without oral presentation

  • 6. Compulsory reading – study material

    Course document : Magnetic Resonance Imaging of the nervous system (Dr. M. Verhoye)

    An electronic version of the presentations can be downloaded from Blackboard. A print out of the presentations (2 hand-out/page) can be bought at the reprography of the University of Antwerp.



    7. Recommended reading - study material

    Medical Imaging Physics, 4th ed. William R. Hendee, E. Russell Ritenour, ed. Wiley-Liss, 2002 , NY-ISBN 0-471-38226-4


    Fundamentals of Medical Imaging, Paul Suetens
    Publisher: Cambridge University Press; Bk&CD-Rom edition (March 2002)
    ISBN: 0521803624


    MRI From picture to proton, Donald W. McRobbie, Elizabeth A. Moore, Martin J. Graves, Martin R. Prince,

    Publisher: CambridgeUniversity Pres, ISBN 0-521-68384-X paperback


    Radiobiology for the Radiologist, 6th ed. Eric J. Hall, Amato J. Giacca

    Lippincott Williams & Wilkins, 2006, ISBN 0781741513


    Medical Imaging, Signals and Systems, Jerry L. Prionce, Jonathan M. Links, Pearson Edudaction, ISBN 0-13-065353-5


    8. Tutoring

    You can always ask the teacher questions after or during the pause of a contact moment.

    Beyond the contact moments, students are asked to contact the teacher in order to make an appointment.


    Dr. Marleen Verhoye
    University of Antwerp, Campus Groenenborger (CGB)

    Groenenborgerlaan, 171
    B-2020 Antwerp
    Tel:       ++ 32 (0)3 2653389

                ++ 32 (0)3 2653230 
    Fax.      ++ 32 (0)3 2653233


    laatste aanpassing: last update: 13/11/2009 09:32 marleen.verhoye