Data Collection and Processing

Academic year: 2010-2011 Course code module 1BBMW-041 Semester: 1st and 2nd semester Credits: 4 Study load (hours) 112 Theory (hours): 15,00 Practice/Exercises(hours): Other (hours): 15,00 Part-time program: 1 Instructor(s) Marc Braem Marleen Verhoye Filip Lemiere Language of instruction: Dutch Semester exam information: exam in the 1st and/or 2nd semester Contract restriction information: exam contract not possible 1. Prerequisites *Algemene competenties Basi knowledge of the English language is required since most papers that need to be discussed will be written in English. The student only needs an 'end-user' capability regarding the personal computer. *Sequentiality None 2. Objectives (expected learning outcomes) The student must be able to solve a limited and well-defined problem in the biomedical field, using search engines and library databases, all in an autonomous way. 3. Course content The course is mainly ¿hands-on¿ in the computer class, after a theoretical introduction on library catalogues, databases, search engines etc. At the same time, there will be a basic introduction in the use of the Windows operating system from the point of view of an end-user, as well as on frequently used office software and Windows-based email software. The topics of the search will be situated in the biomedical field, coming from chemistry, cellbiology, histology, anatomy and so on. Next, the student will have to show their ability to use the search engines in such a way that within a limited amount of time, a solution can be provided for a well-defined problem in the biomedical field. All this is done interactively and by using electronic post. 4. Teaching method Direct contact: Lectures Exercise sessions 5. Assessment method Exam: Open book Multiple choice Open questions Written assignment: Without oral presentation 6. Compulsory reading – study material Adequate notes will be available through the Internet. 7. Recommended reading - study material General literature regarding search activities on the internet, basics about word processing and spreadsheets. 8. Tutoring laatste aanpassing: last update: 01/06/2006 01:01 ecampus

Physics

Academic year: 2010-2011 Course code module 1BDIE-011 Semester: 1st semester Credits: 4 Study load (hours) 112 Theory (hours): 30,00 Practice/Exercises(hours): Other (hours): 5,00 Part-time program: 1 Instructor(s) Marleen Verhoye Language of instruction: Dutch Semester exam information: exam in the 1st semester Contract restriction information: 1. Prerequisites *Algemene competenties The course physics is algebra based. This means that little calculus mathematical principles are used (differential, integral). The student should have a good basic knowledge of mathematics (vectors, derivatives, goniometric functions, algebra, equations, solving set of equations (classic method); be able to analyze simple problems (difference data/unknowns; relevance of data and relations between data) and translate them into a suitable mathematical context. The course leans towards physics seen in secondary school. *Sequentiality None 2. Objectives (expected learning outcomes) What are you considered to know/be able at the end of this course?  • you have insight in the physical variables, the basic concepts and equations: you can describe these in your own words, recognize, formulate, give examples of the physical processes; • you can apply the physical laws in simple problems; you can analyze the physical problem and translate to appropriate mathematical /physical context and solve it;  • you have sufficient insight in the physical processes to understand physiological processes in your veterinary education;  • you can critically assess the acceptability and validity of obtained results; you can estimate the magnitude of calculated or measured variables;  • you can relate the physical processes to the discussed biomedical processes or the measuring methods of biomedical parameters; • you can analyze independently simple biomedical applications/problems and translate them to an appropriate mathematical/physical context and solve; • you can search independently scientific literature, describe papers in your own words and interpret • you have computer skills, you know the basic possibilities of a word processing programme and can use these to write a paper • you can create a structured and well-organised paper • you can function in a team 3. Course content The course content is tuned to the prerequisites which are needed for the other courses in the Bachelor Veterinary education. This course gives the needed basis to obtain insight in the physical laws underlying several biophysical and physiological processes in living organisms. Mechanics (kinematics, dynamics, collisions, rotation, balance), liquids and gasses, vibrations, sound, heat, electricity and magnetism, optics).   Different biomedical applications of these physical laws will be discussed (muscle forces, fluida and the cardio-vascular system, elektro-cardiography, signal transport in axons,.. etc.) Students have the assignment to make a project (written) about the biomedical/veterinarian applications of the physical laws. 4. Teaching method Direct contact: Lectures Exercise sessions Personal work: Assignments - in group Paper - in group Portfolio 5. Assessment method Exam: Written, without oral presentation Multiple choice Written assignment: Without oral presentation Portfolio: Without oral presentation 6. Compulsory reading – study material The content of the course 'Physics' is based on an Englisch book "Physics" of James S.Walker, ed. Pearson. "Physics" van James S.Walker, ed. Pearson. Upper Saddle River , New Jersey07458     Pearson / Prentice Hall     2007 (also 2e edition 2004 can be used)     ISBN: 0 – 13 – 227019 - 6         (possibility to buy at the reprography CGB)   The presentations also contain additional descriptions of the physical laws underlying several biophysical and physiological processes in living organisms . These also belong to the subject matter unless this it is explicitly indicated in the lectures that it is only given for information/demonstration. PowerPoint presentations are in Dutch and have been based on the basis physics which is treated in the textbook. The presentations explicitly reflect the Dutch translation of the English terms of the textbook.   An electronic version of the presentations can be downloaded from Blackboard. A print out of the presentations (2 hand-outs/page) can be bought at the reprography of the University of Antwerp. 7. Recommended reading - study material UA-campus library CGB Natuurkunde voor wetenschap en techniek. 1: Mechanica Giancoli, Douglas C. Natuurkunde voor wetenschap en techniek. 2: Golven en geluid, kinetische theorie en thermodynamica, elektriciteit en magnetisme, licht Giancoli, Douglas C.; Physics : principles with applications Giancoli, Douglas C. Englewood Cliffs, N.J., 1995 8. Tutoring You can always ask the teacher small questions after or during the pause of a contact moment. Moreover you can get help from the education assistance of the faculty FBD for specific study advice and help: - tutoring physics (and mathematics) Tania Solomaniuck:     e-mail: tania.solomaniuck@ ua.ac.be     tel: 03/265 34 60     office: S322, at the back of library  - DSSB (psychological/general help or advice)   week 3, Thursday 14 Oktober and week 4, Thursday 21 Oktober 16:00-18:00 How to study the course Physics - Solomaniuck, Tania G.T.105.   laatste aanpassing: last update: 04/08/2010 10:22 marleen.verhoye

In-vivo biomedical imaging techniques

Academic year: 2010-2011 Course code module 1MBMW-K-019 Semester: 1st semester Credits: 6 Study load (hours) 168 Theory (hours): 25,00 Practice/Exercises(hours): 15,00 Other (hours): 15,00 Part-time program: 1 Instructor(s) Marleen Verhoye Johan Van Goethem Language of instruction: Dutch Semester exam information: exam in the 1st semester Contract restriction information: 1. Prerequisites *Algemene competenties The prequisites of 'In-vivo biomedical imaging techniques in pre-clinical and clinical context' is closely connected to the objectives of the 'Physics' course (1st Ba). Physical variables/principles which were not discussed in the course 'Physics' , and which are necessary for a good understanding of the subject matter are treated within the course. The student must have a sufficient mathematical basic knowledge (vectors, derivatives, simple goniometrical functions, algebra, equations, solving set of equations (classical methods); basic principles of calculus (differential and integral - secondary school). *Sequentiality None 2. Objectives (expected learning outcomes) What are you considered to know/be able at the end of this course?   You have insight in the interaction of radiation with matter and patients; You have insight in the physical principles of different imaging techniques and their practical use in modern imaging instrumentation; you can describe these in your own words, recognize, formulate; you have insight in the reconstruction of different image modalities and the physical parameter which is being visualized (eg. absorption, reflection, transmission, scattering, energy, radioactive decay, frequency shift, energy of nucleus in extern magnetic field, temperature,..); you can describe these in your own words, recognize, formulate; for each of the discussed imaging techniques you can describe the origin of the image intensities; you can explain why specific tissues are represented dark or bright in the images; you have insight how different imaging techniques can be used in a preclinical and a clinical context 3. Course content The course discusses both the physical principles, image reconstruction and the clinical and preclinical applications of the different biomedical imaging modalities: interaction of radiation with matter X-ray imaging and CT-scan: instrumentation,  interaction of X-radiation with matter and patients, possibilities of imaging, image reconstruction, artifacts Echography with ultrasound: instrumentation, interaction US wave with matter, possibilities of imaging (A,B,M-mode-real time), Doppler ultrasound Magnetic Resonance Imaging: instrumentation, origin of the MR signal, image contrast, image reconstruction Radionuclide imaging: scintigraphy, SPECT and PET, radioactivity and detectors   During the practical demonstrations (MRI,CT,US,PET), students are given a first introduction to the operation of the different imaging modalities used for biomedical imaging and research on animals and patients. 4. Teaching method Direct contact: Lectures Practical sessions Personal work: Assignments - individual Paper - individual 5. Assessment method Exam: Written, without oral presentation Oral, with written preparation Multiple choice Open questions Written assignment: Without oral presentation 6. Compulsory reading – study material Course documents An electronic version of the presentations can be downloaded from Blackboard. A print out of the presentations (2 hand-out/page) can be bought at the reprography of the University of Antwerp. 7. Recommended reading - study material Medical Imaging Physics, 4th ed. William R. Hendee, E. Russell Ritenour, ed. Wiley-Liss, 2002 , NY-ISBN 0-471-38226-4   Fundamentals of Medical Imaging, Paul Suetens Publisher: Cambridge University Press; Bk&CD-Rom edition (March 2002) ISBN: 0521803624   MRI From picture to proton, Donald W. McRobbie, Elizabeth A. Moore, Martin J. Graves, Martin R. Prince, Publisher: CambridgeUniversity Pres, ISBN 0-521-68384-X paperback   Radiobiology for the Radiologist, 6th ed. Eric J. Hall, Amato J. Giacca Lippincott Williams & Wilkins, 2006, ISBN 0781741513 8. Tutoring You can always ask the teacher questions after or during the pause of a contact moment. laatste aanpassing: last update: 14/10/2009 14:47 marleen.verhoye

In-vivo biomedical imaging techniques in pre-clinical and clinical context

Academic year: 2010-2011 Course code module 1MBMW-K-0191 Semester: 1st semester Credits: 6 Study load (hours) 168 Theory (hours): 25,00 Practice/Exercises(hours): 15,00 Other (hours): 15,00 Part-time program: 1 Instructor(s) Marleen Verhoye Johan Van Goethem Language of instruction: Dutch Semester exam information: exam in the 1st semester Contract restriction information: exam contract not possible 1. Prerequisites *Algemene competenties The prerequisites of 'In-vivo biomedical imaging techniques in pre-clinical and clinical context' is closely connected to the objectives of the 'Physics' course (1st Ba). Physical variables/principles which were not discussed in the course 'Physics' , and which are necessary for a good understanding of the subject matter are treated within the course. The student must have a sufficient mathematical basic knowledge (vectors, derivatives, simple goniometrical functions, algebra, equations, solving set of equations (classical methods); basic principles of calculus (differential and integral - secondary school). *Sequentiality None A credit has to be obtained for all courses in Ba1 and Ba2. 2. Objectives (expected learning outcomes) What are you considered to know/be able at the end of this course?   You have insight in the interaction of radiation with matter and patients; You have insight in the physical principles of different imaging techniques and their practical use in modern imaging instrumentation; you can describe these in your own words, recognize, formulate; you have insight in the reconstruction of different image modalities and the physical parameter which is being visualized (eg. absorption, reflection, transmission, scattering, energy, radioactive decay, frequency shift, energy of nucleus in extern magnetic field, temperature,..); you can describe these in your own words, recognize, formulate; for each of the discussed imaging techniques you can describe the origin of the image intensities; you can explain why specific tissues are represented dark or bright in the images; you have insight how different imaging techniques can be used in a preclinical and a clinical context 3. Course content The course discusses both the physical principles, image reconstruction and the clinical and preclinical applications of the different biomedical imaging modalities: interaction of radiation with matter X-ray imaging and CT-scan: instrumentation,  interaction of X-radiation with matter and patients, possibilities of imaging, image reconstruction, artifacts Echography with ultrasound: instrumentation, interaction US wave with matter, possibilities of imaging (A,B,M-mode-real time), Doppler ultrasound Magnetic Resonance Imaging: instrumentation, origin of the MR signal, image contrast, image reconstruction Radionuclide imaging: scintigraphy, SPECT and PET, radioactivity and detectors   During the practical demonstrations (MRI,CT,US,PET), students are given a first introduction to the operation of the different imaging modalities used for biomedical imaging and research on animals and patients. 4. Teaching method Direct contact: Lectures Practical sessions Personal work: Assignments - individual Paper - individual 5. Assessment method Exam: Written, without oral presentation Oral, with written preparation Multiple choice Open questions Written assignment: Without oral presentation 6. Compulsory reading – study material Course documents An electronic version of the presentations can be downloaded from Blackboard. A print out of the presentations (2 hand-out/page) can be bought at the reprography of the University of Antwerp.   7. Recommended reading - study material Medical Imaging Physics, 4th ed. William R. Hendee, E. Russell Ritenour, ed. Wiley-Liss, 2002 , NY-ISBN 0-471-38226-4   Fundamentals of Medical Imaging, Paul Suetens Publisher: Cambridge University Press; Bk&CD-Rom edition (March 2002) ISBN: 0521803624   MRI From picture to proton, Donald W. McRobbie, Elizabeth A. Moore, Martin J. Graves, Martin R. Prince, Publisher: CambridgeUniversity Pres, ISBN 0-521-68384-X paperback   Radiobiology for the Radiologist, 6th ed. Eric J. Hall, Amato J. Giacca Lippincott Williams & Wilkins, 2006, ISBN 0781741513 8. Tutoring You can always ask the teacher questions after or during the pause of a contact moment. laatste aanpassing: last update: 14/11/2008 17:30 marleen.verhoye

Principles of in vivo biomedical imaging, preclinical and clinical studies

Academic year: 2010-2011 Course code module 1MBMW-K-0192 Semester: 1st semester Credits: 6 Study load (hours) 168 Theory (hours): 25,00 Practice/Exercises(hours): 15,00 Other (hours): 15,00 Part-time program: 1 Instructor(s) Marleen Verhoye Johan Van Goethem Language of instruction: English Semester exam information: exam in the 1st semester Contract restriction information: exam contract not possible 1. Prerequisites *Algemene competenties The prerequisites of 'In-vivo biomedical imaging techniques in pre-clinical and clinical context' is closely connected to the objectives of the 'Physics' course (1st Ba). Physical variables/principles which were not discussed in the 'Physics' course context,  still which are rather necessary for a good understanding of the subject matter are considered within this course. The student must have a sufficient knowledge in basic mathematical (vectors, derivatives, simple goniometrical functions, algebra, equations, solving set of equations (classical methods); basic principles of calculus (differential and integral - secondary school). *Sequentiality None 2. Objectives (expected learning outcomes) What are you considered to know/anticipate by pursuing this course?   You have insight in the interaction of radiation with matter and patients; You have developed an insight in the physical principles of different imaging techniques and their practical use in modern imaging instrumentation; you are potentially able to describe these in your own words, recognize and formulate; you have developed an insight in the reconstruction of different image modalities and the physical parameter which is being visualized (eg. absorption, reflection, transmission, scattering, energy, radioactive decay, frequency shift, energy of nucleus in extern magnetic field, temperature,..); you are potentially able to describe these in your own words, recognize, formulate; for each of the discussed imaging techniques you are able to describe the origin of the image intensities; you are able to explain why specific tissues are represented dark or bright in the images; you have developed an insight how different imaging techniques can be used in a preclinical and a clinical context. 3. Course content The course discusses the physical principles, image reconstruction and clinical & preclinical applications of the different biomedical imaging modalities: interaction of radiation with matter X-ray imaging and CT-scan: instrumentation,  interaction of X-radiation with matter and patients, possibilities of imaging, image reconstruction, artifacts Echography with ultrasound: instrumentation, interaction US wave with matter, possibilities of imaging (A,B,M-mode-real time), Doppler ultrasound Magnetic Resonance Imaging: instrumentation, origin of the MR signal, image contrast, image reconstruction Radionuclide imaging: scintigraphy, SPECT and PET, radioactivity and detectors   During the practical demonstrations (MRI,CT,US,PET), students will be introduced to the operation of the different imaging modalities being used for biomedical imaging and research on laboratory animals and patients.   4. Teaching method Direct contact: Lectures Practical sessions Personal work: Assignments - individual Paper - individual 5. Assessment method Exam: Oral, with written preparation Multiple choice Open questions Written assignment: Without oral presentation 6. Compulsory reading – study material Course documents An electronic version of the presentations can be downloaded from Blackboard. A print out of the presentations (2 hand-out/page) can be bought at the reprography of the University of Antwerp.   websites 7. Recommended reading - study material Medical Imaging Physics, 4th ed. William R. Hendee, E. Russell Ritenour, ed. Wiley-Liss, 2002 , NY-ISBN 0-471-38226-4   Fundamentals of Medical Imaging, Paul Suetens Publisher: Cambridge University Press; Bk&CD-Rom edition (March 2002) ISBN: 0521803624   MRI From picture to proton, Donald W. McRobbie, Elizabeth A. Moore, Martin J. Graves , Martin R. Prince, Publisher: CambridgeUniversity Pres, ISBN 0-521-68384-X paperback   Radiobiology for the Radiologist, 6th ed. Eric J. Hall, Amato J. Giacca Lippincott Williams & Wilkins, 2006, ISBN 0781741513   Medical Imaging, Signals and Systems, Jerry L. Prionce, Jonathan M. Links, Pearson Edudaction, ISBN 0-13-065353-5   8. Tutoring You can always ask the teacher questions after or during the pause of a contact moment. laatste aanpassing: last update: 13/10/2010 13:54 marleen.verhoye

Neuroimaging

Academic year: 2010-2011 Course code module 1MBMW-K-022 Semester: 1st semester Credits: 6 Study load (hours) 168 Theory (hours): 35,00 Practice/Exercises(hours): 30,00 Other (hours): Part-time program: 2 Instructor(s) Anne Marie Van Der Linden Marleen Verhoye Paul Parizel Language of instruction: English Semester exam information: exam in the 1st semester Contract restriction information: 1. Prerequisites *Algemene competenties Bachelor students which have basic knowledge of the structure and function of the human body in terms of anatomy, histology and physiology.  More specific, the course assumes knowledge of the anatomy of the nervous system and the physiology of different cells of the CNS including the blood vessels knowledge of neurotransmission and neuro receptors.   *Sequentiality None 2. Objectives (expected learning outcomes) What are you considered to know/anticipate to have learnt by the end of this course?   you have developed a thorough knowledge of the newest imaging techniques and of their significance and application in imaging the central nervous system ; You have developed an insight in the physical principles of different imaging techniques and their practical use in modern imaging instrumentation; you are able to  describe these in your own words, recognize, formulate; you have developed an insight in the reconstruction of different image modalities and the physical parameter which is being visualized (3D techniques, diffusion, perfusion, neural activity, macroscopic flow, angiography, contrast agents); you are able to  describe these in your own words, recognize, formulate; for each of the discussed imaging techniques you are able to  describe the origin of the image intensities both at the level of the acquisition parameters and the quantitative image processing ; you are able to explain why specific tissues are represented dark or bright in the images; you have developed an insight on how different imaging techniques can be used in a preclinical and a clinical context you know the different image modalities - and their principles - to visualize brain activity and can describe the complementarily among the techniques you know which imaging techniques can support which aspect of brain research you have a thorough knowledge concerning the use of PET in preclinical and clinical neuro applications.   3. Course content The course is considered as an integrated practical course in which the different techniques of neuroimaging are dealt with. The applications, indication and medical value of all techniques of neuroimaging will be discussed and illustrated by means of literature or practical examples.  Appropriate levels of attention will be devoted to the advanced image processing used in biomedical research.     The course also gives insight in how image contrasts can be acquired (technically) and what are the underlying physiological or anatomical mechanisms for each image contrast.   In the introduction the anatomy/MRI and existing neuroatlasses are compared between humans (clinical) and rodents (rat/mouse) (preclinical).   In the  magnetic resonance imaging (MRI) section focus is made towards MRI contrast agents and their applicability in both preclinical and  clinical context, diffusion MRI and application of DW MRI in several applications (stroke, MS,  development/degeneration white matter), perfusion weighted MRI with application of PW MRI in several applications (ischemia, brain tumors), MRI functional for brain functioning, flow and MR angiography with applications, ultrafast imaging with applications (use in fMRI, quantification volume brain regions), and leakage of blood-brain-barrier with dynamic MRI with use of contrast agents. Moreover both MR Spectroscopy and MR spectroscopic imaging is discussed, including their underlying principles and the neuro applications in preclinical and clinical context. In the  PET-MRI section the use of relevant tracers for neuro research in preclinical and clinical context is discussed. This technique however is more described in detail in the course ‘Molecular Imaging representation in preclinical and clinical’ context.     The students will be able to perform MR experiments.  The practical course is focused on the different MR techniques and the acquired physiological parameters (obtained using customized image processing techniques). 4. Teaching method Direct contact: Lectures Practical sessions 5. Assessment method Exam: Written, without oral presentation Oral, with written preparation Multiple choice Open questions Continuous assessment: Assignments Written assignment: Without oral presentation Presentation 6. Compulsory reading – study material Course document : Magnetic Resonance Imaging of the nervous system (Dr. M. Verhoye) An electronic version of the presentations can be downloaded from Blackboard. A print out of the presentations (2 hand-out/page) can be bought at the reprography of the University of Antwerp.   7. Recommended reading - study material Medical Imaging Physics, 4th ed. William R. Hendee, E. Russell Ritenour, ed. Wiley-Liss, 2002 , NY-ISBN 0-471-38226-4   Fundamentals of Medical Imaging, Paul Suetens Publisher: Cambridge University Press; Bk&CD-Rom edition (March 2002) ISBN: 0521803624   MRI From picture to proton, Donald W. McRobbie, Elizabeth A. Moore, Martin J. Graves, Martin R. Prince, Publisher: CambridgeUniversity Pres, ISBN 0-521-68384-X paperback   Radiobiology for the Radiologist, 6th ed. Eric J. Hall, Amato J. Giacca Lippincott Williams & Wilkins, 2006, ISBN 0781741513   Medical Imaging, Signals and Systems, Jerry L. Prionce, Jonathan M. Links, Pearson Edudaction, ISBN 0-13-065353-5 8. Tutoring You can always ask the teacher questions after or during the pause of a contact moment.   contact person: Dr. Marleen Verhoye BioImagingLab University of Antwerp, Campus Groenenborger (CGB) Groenenborgerlaan, 171 B-2020 Antwerp Belgium Tel:       ++ 32 (0)3 2653389             ++ 32 (0)3 2653230  Fax.      ++ 32 (0)3 2653233 email: Marleen.Verhoye@ua.ac.be http://webhost.ua.ac.be/biomag/   laatste aanpassing: last update: 28/10/2010 11:57 marleen.verhoye

Neuroimaging, preclinical and clinical studies

Academic year: 2010-2011 Course code module 1MBMW-K-0222 Semester: 1st semester Credits: 6 Study load (hours) 168 Theory (hours): 35,00 Practice/Exercises(hours): 15,00 Other (hours): 5,00 Part-time program: 1 Instructor(s) Marleen Verhoye Anne Marie Van Der Linden Paul Parizel Language of instruction: English Semester exam information: exam in the 1st semester Contract restriction information: exam contract not possible 1. Prerequisites *Algemene competenties Students should have basic knowledge of the structure and function of the human body in terms of anatomy, histology and physiology.  More specific, the course assumes knowledge of the anatomy of the nervous system and the physiology of different cells of the CNS including the aspects of blood vessels integral in neurotransmission and neuroreceptors (see course Neuroscience Ba3) . K nowledge of the principles of different imaging techniques, b asic mathematics and digital signal processing are required to understand the different image acquisitions and image reconstruction techniques. *Sequentiality Principles of in vivo biomedical imaging, preclinical and clinical studies (1MBMW-K-0192) OR In-vivo biomedical imaging techniques in pre-clinical and clinical context (1MBMW-K-0191) 2. Objectives (expected learning outcomes) What are you considered to know/anticipate to have learnt by the end of this course?   you have developed a thorough knowledge of the newest imaging techniques and of their significance and application in imaging the central nervous system ; You have developed an insight in the physical principles of different imaging techniques and their practical use in modern imaging instrumentation; you are able to  describe these in your own words, recognize, formulate; you have developed an insight in the reconstruction of different image modalities and the physical parameter which is being visualized (3D techniques, diffusion, perfusion, neural activity, macroscopic flow, angiography, contrast agents); you are able to  describe these in your own words, recognize, formulate; for each of the discussed imaging techniques you are able to  describe the origin of the image intensities both at the level of the acquisition parameters and the quantitative image processing ; you are able to explain why specific tissues are represented dark or bright in the images; you have developed an insight on how different imaging techniques can be used in a preclinical and a clinical context you know the different image modalities - and their principles - to visualize brain activity and can describe the complementarily among the techniques you know which imaging techniques can support which aspect of brain research you have a thorough knowledge concerning the use of PET in preclinical and clinical neuro applications. 3. Course content The course is considered as an integrated practical course in which the different techniques of neuroimaging are dealt with. The applications, indication and medical value of all techniques of neuroimaging will be discussed and illustrated by means of literature or practical examples.  Appropriate levels of attention will be devoted to the advanced image processing used in biomedical research.     The course also gives insight in how image contrasts can be acquired (technically) and what are the underlying physiological or anatomical mechanisms for each image contrast.   In the introduction the anatomy/MRI/CT and existing neuroatlasses are compared between humans (clinical) and rodents (rat/mouse) (preclinical).   In the  computer tomography (CT) section focus is made towards CT contrast agents and their applicability in preclinical and clinical context, perfusion CT, 3D techniques and CT-angiography.   In the  magnetic resonance imaging (MRI) section focus is made towards MRI contrast agents and their applicability in both preclinical and  clinical context, diffusion MRI and application of DW MRI in several applications (stroke, MS,  development/degeneration white matter), perfusion weighted MRI with application of PW MRI in several applications (ischemia, brain tumors), MRI functional for brain functioning, flow and MR angiography with applications, ultrafast imaging with applications (use in fMRI, quantification volume brain regions), and leakage of blood-brain-barrier with dynamic MRI with use of contrast agents. Moreover both MR Spectroscopy and MR spectroscopic imaging is discussed, including their underlying principles and the neuro applications in preclinical and clinical context. In the  PET-MRI section the use of relevant tracers for neuro research in preclinical and clinical context is discussed. This technique however is more described in detail in the course ‘Molecular Imaging representation in preclinical and clinical’ context.     The students will be able to perform MR and CT experiments.  The practical course is focused on the different MR techniques and the acquired physiological parameters (obtained using customized image processing techniques). Lecture 1 and lecture 2 are the MRI basic from 'Principles in vivo biomedical imaging", co not mandatory but STRONGLY ADVISED.     Day scheduled time location programmed lectures         Mon 8 Nov 10 10.30-12.30 G.T.129 WELCOME_tour university    13.45-17.45 G. U.2.41 Lecture 1: MRI-contrast principles         Tue 9 Nov 10 8.30-12.30 G. U.2.44 Lecture 2: MR imaging principles   13.45-17.15 BIL       Practice 1- group 1 & 2 (MR imaging general)         Wed 10 Nov 10 8.30-12.30 G. U.2.44 Lecture 3: Flow effects, flow imaging, angiography   13.45-17.45 D.R.019 Lecture 4: Translat. anatomy: mice/rat-atlas Lecture 5: MRI basic clinical and preclinical imaging    Thu 11 Nov 10     holiday   Fri 12 Nov 10     holiday         Mon 15 Nov 10 12.30-13.40 G. U.2.41 IP-students: financial administration 13.45-17.45 G. U.2.41 Lecture 6: Diffusion and perfusion   Tue 16 Nov 10 10.45-12.45 G. U.0.26 Lecture 7: MRS   13.45-17.15 BIL       Practice 1- group 3 & 4 (MR imaging general)         Wed 17 Nov 10 9.00-12.30 BIL       Practice 1 - group 5 & 6 (MR imaging general)   13.45-17.45 D.R.008  Lecture 8a: Advanced clinical MRI: sequences, MRS, perfusion, diffusion           MR imaging sequences: from physical principles to practical protocols           MR spectroscopy for dummies           Stroke and perfusion imaging           Causes of diffusion restriction                                                                   Lecture 8b: Advanced clinical MRI: Perfusion & Spinal degeneration   Thu 18 Nov 10 9.00-12.30         Practice 2- group 1 & 2 (MR diffusion imaging)   13.45-17.45 BIL       Practice 2- group 3 & 4 (MR diffusion imaging)         Fri 19 Nov 10 9.00-12.30 BIL       Practice 2- group 5 & 6 (MR diffusion imaging)   13.45-17.45 G. U.0.26   Lecture 9: Compl. methods for Neuroimaging : Optical/ PET   Mon 22 Nov 10 9.00-11.00 BIL       Practice 3- group 1 & 2 (perfusion)   11.00-13.00 BIL       Practice 3- group 3 & 4 (perfusion)   13.45-15.45 BIL       Practice 3- group 5 & 6 (perfusion)         Tue 23 Nov 10 8.30-12.30 G. U.2.44 Lecture 10: fMRI   13.45-17.45 BIL       Practice 4- group 1 & 2 (fMRI)         Wed 24 Nov 10 8.30-12.30 D.R.0.08 Lecture 8c:  Advanced clinical MRI – tumors, Multiparametric imaging of brain tumors (characterization, diffusion, perfusion, spectroscopy) Lecture 8d:  Advanced clinical MRI – DTI,  Introduction to diffusion tensor imaging   17.00-21.00 UZA       Practice 5- group 1 & 2 & 3 (human MRI)                 Thu 25 Nov 10 9.00-13.00 BIL       Practice 4- group 3 & 4 (fMRI)   17.00-21.00 UZA       Practice 5- group 3 & 4 & 5 (human MRI)         Fri 26 Nov 10 8.30-12.30 G. U.2.44 Lecture 11: Contrast Agents  & ME     13.45-17.45 BIL       Practice 4- group 5 & 6 (fMRI)         Mon 29 Nov 10 8.30-12.30 D.R.0.07-D.R.0.08 Exam "IP NeuroMRI" ,  Marleen, Johan Van Goethem   possible two sessions, so also an afternoon exam Wed 1 Dec 10 8.30-12.30 D.R.0.09 Lecture : Spinal Imaging: CT & MR (JVG)         Wed 1 Dec 10 17,00-21,00 UZA       Practice CT (1 group) examen Neuroimaging (MRI & CT)voor UA studenten, in examen periode (januari 2011) 4. Teaching method Direct contact: Lectures Practical sessions 5. Assessment method Exam: Oral, with written preparation Open questions Continuous assessment: Exercises Assignments Participation in classroom activities Written assignment: Without oral presentation 6. Compulsory reading – study material Course document : Magnetic Resonance Imaging of the nervous system (Dr. M. Verhoye) An electronic version of the presentations can be downloaded from Blackboard. A print out of the presentations (2 hand-out/page) can be bought at the reprography of the University of Antwerp.   websites 7. Recommended reading - study material Medical Imaging Physics, 4th ed. William R. Hendee, E. Russell Ritenour, ed. Wiley-Liss, 2002 , NY-ISBN 0-471-38226-4   Fundamentals of Medical Imaging, Paul Suetens Publisher: Cambridge University Press; Bk&CD-Rom edition (March 2002) ISBN: 0521803624   MRI From picture to proton, Donald W. McRobbie, Elizabeth A. Moore, Martin J. Graves, Martin R. Prince, Publisher: CambridgeUniversity Pres, ISBN 0-521-68384-X paperback   Radiobiology for the Radiologist, 6th ed. Eric J. Hall, Amato J. Giacca Lippincott Williams & Wilkins, 2006, ISBN 0781741513   Medical Imaging, Signals and Systems, Jerry L. Prionce, Jonathan M. Links, Pearson Edudaction, ISBN 0-13-065353-5   8. Tutoring You can always ask the teacher questions after or during the pause of a contact moment. Beyond the contact moments, students are asked to contact the teacher in order to make an appointment.   Dr. Marleen Verhoye BioImagingLab University of Antwerp, Campus Groenenborger (CGB) Groenenborgerlaan, 171 B-2020 Antwerp Belgium Tel:       ++ 32 (0)3 2653389             ++ 32 (0)3 2653230  Fax.      ++ 32 (0)3 2653233 email: Marleen.Verhoye@ua.ac.be http://webhost.ua.ac.be/biomag/ laatste aanpassing: last update: 28/10/2010 11:55 marleen.verhoye

Radio protection and introduction to medical imaging

Academic year: 2010-2011 Course code module 3BDIE-70 Semester: 1st semester Credits: 3 Study load (hours) 84 Theory (hours): 23,00 Practice/Exercises(hours): Other (hours): Part-time program: 1 Instructor(s) Marleen Verhoye Ivan Huyghe Language of instruction: Dutch Semester exam information: exam in the 1st semester Contract restriction information: exam contract not possible 1. Prerequisites *Algemene competenties The prerequisites of Radio protection and introduction to medical imaging ' is closely connected to the objectives of the 'Physics' course (1st Ba). Physical variables/principles which were not discussed in the course 'Physics' , and which are necessary for a good understanding of imaging techniques and radioprotection are treated within the course. The student must have a sufficient mathematical basic knowledge (vectors, derivatives, simple goniometrical functions, algebra, equations, solving set of equations (classical methods); basic principles of calculus (differential and integral - secondary school). *Sequentiality Physics (1BDIE-011) 2. Objectives (expected learning outcomes) What are you considered to know/be able at the end of this course?   imaging You have insight in the interaction of radiation with matter; You have insight in the physical principles of different imaging techniques and their practical use in modern imaging instrumentation; you can describe these in your own words, recognize, formulate; you have insight in the reconstruction of different image modalities and the physical parameter which is being visualized (eg. absorption, reflection, transmission, scattering, energy, radioactive decay, frequency shift, energy of nucleus in extern magnetic field, temperature,..); you can describe these in your own words, recognize, formulate; for each of the discussed imaging techniques you can describe the origin of the image intensities; you can explain why specific tissues are represented dark or bright in the images;   radioprotection You have knowledge of radioactivity, what is ionizing radiation ( (α-, β-, γ-, en X-radiation) and how do they i nteract with matter; you have insight in de different methods to measure ionizing radiation, thorough knowledge of the detectors and/or measure methods, the units in which radiation doses are given (dosimeter); you have knowledge of the biological impact of ionizing radiation (at molecular (DNA), cellular, tissular and organic level) and insight in the distinct deterministical and stochastical effects you are familiar with the basic principles of radioprotection (justification, optimalisation and dose limitation) en have command of the elementary radioprotection proceedings (distance, time, shielding); you have basic knowledge of Radioecology (natural and artificial  radioactivity, transfer modalities and kind of contamination), including sufficient knowledge of the radiological bio-indicators; you have insight in the radiological emergence- and contingency plan especially focussed on the proceedings in the agro sector and the cattle breeding (protection of the food chain), yet without excluding the plan with respect to small pet(animals); you have insight in and are familiar with the rules and law regarding ionizing radiation (National: ARBIS, K.B. of 20 juli 2001, European: Guidelines, International: ICRP-documents). 3. Course content part1: Marleen Verhoye The course discusses both the physical principles, image reconstruction and the clinical and preclinical applications of the different biomedical imaging modalities: interaction of radiation with matter X-ray imaging and CT-scan: instrumentation,  interaction of X-radiation with matter and patients, possibilities of imaging, image Echography with ultrasound: instrumentation, interaction US wave with matter, possibilities of imaging (A,B,M-mode-real time), Doppler ultrasound Magnetic Resonance Imaging: instrumentation, origin of the MR signal, image contrast, image reconstruction (limited) radioactivity: radioactive radiation, variables, units and radioactive decay   part 2: Ivan Huyghe 1.      biological aspecs of ionizing radiation 2.      dosimetry: Why is it needed? How where the proceedings historically created, and how are they adapted? 3.      rules and law regarding ionizing radiation is discussed from a practical point of view 4.      detectors: low doses; gamma-camera/PET 5.      tracers: generator concept (Molybdeen–Technetium) examples of tracers actually used in veterinary;  6.      Radionuclide imaging: planar scintigraphy, SPECT and introduction to PET and fusion techniques (PET-CT and SPECT-CT) 7.      Therapy with Jodium 131   The students are invited to follow a demonstration of an MRI-experiment (campus CGB), and human nuclear imaging (UZA).  After the US college, a US demonstration will be performed on an animal (Peter Bols, CDE).     These practical demonstrations (MRI, US,PET) give the students a first introduction to the operation of the different imaging modalities used for biomedical imaging. 4. Teaching method Direct contact: Lectures 5. Assessment method Exam: Oral, with written preparation Open questions 6. Compulsory reading – study material   Course documents An electronic version of the presentations can be downloaded from Blackboard. A print out of the presentations (2 hand-out/page) can be bought at the reprography of the University of Antwerp. 7. Recommended reading - study material Medical Imaging Physics, 4th ed. William R. Hendee, E. Russell Ritenour, ed. Wiley-Liss, 2002 , NY-ISBN 0-471-38226-4   Fundamentals of Medical Imaging, Paul Suetens Publisher: Cambridge University Press; Bk&CD-Rom edition (March 2002) ISBN: 0521803624   MRI From picture to proton, Donald W. McRobbie, Elizabeth A. Moore, Martin J. Graves, Martin R. Prince, Publisher: CambridgeUniversity Pres, ISBN 0-521-68384-X paperback   Radiobiology for the Radiologist, 6th ed. Eric J. Hall, Amato J. Giacca Lippincott Williams & Wilkins, 2006, ISBN 0781741513 8. Tutoring   You can always ask the teacher questions after or during the pause of a contact moment. Dr. Marleen Verhoye BioImagingLab University of Antwerp, Campus Groenenborger (CGB) Groenenborgerlaan, 171 B-2020 Antwerp Belgium Tel:       ++ 32 (0)3 2653389             ++ 32 (0)3 2653230  Fax.      ++ 32 (0)3 2653233 email: Marleen.Verhoye@ua.ac.be http://webhost.ua.ac.be/biomag/   laatste aanpassing: last update: 27/07/2010 17:21 marleen.verhoye

Biomedical imaging techniques

Academic year: 2010-2011 Course code module MFYS1018 Semester: 1st semester Credits: 6 Study load (hours) 168 Theory (hours): 25,00 Practice/Exercises(hours): 30,00 Other (hours): Part-time program: 1 Instructor(s) Marleen Verhoye Johan Van Goethem Joris Dirckx Language of instruction: Dutch Semester exam information: exam in the 1st semester Contract restriction information: 1. Prerequisites *Algemene competenties The student must have a sufficient mathematical and physical basic knowledge (Bachelor). *Sequentiality None 2. Objectives (expected learning outcomes) What are you considered to know/anticipate by pursuing this course?   You have insight in the interaction of radiation with matter and patients; You have developed an insight in the physical principles of different imaging techniques and their practical use in modern imaging instrumentation; you are potentially able to describe these in your own words, recognize and formulate; you have developed an insight in the reconstruction of different image modalities and the physical parameter which is being visualized (eg. absorption, reflection, transmission, scattering, energy, radioactive decay, frequency shift, energy of nucleus in extern magnetic field, temperature,..); you are potentially able to describe these in your own words, recognize, formulate; for each of the discussed imaging techniques you are able to describe the origin of the image intensities; you are able to explain why specific tissues are represented dark or bright in the images; you have developed an insight how different imaging techniques can be used in a preclinical and a clinical context. Optical techniques: you know the properties and the use of the most important types of optical microscopes, and you are familiar with some recent optical techniques which are used in the biomedical imaging. 3. Course content The course discusses both the physical principles, image reconstruction and the clinical and preclinical applications of the different biomedical imaging modalities: interaction of radiation with matter X-ray imaging and CT-scan: instrumentation,  interaction of X-radiation with matter and patients, possibilities of imaging, image reconstruction, artifacts Echography with ultrasound: instrumentation, interaction US wave with matter, possibilities of imaging (A,B,M-mode-real time), Doppler ultrasound Magnetic Resonance Imaging: instrumentation, origin of the MR signal, image contrast, image reconstruction Radionuclide imaging: scintigraphy, SPECT and PET, radioactivity and detectors   During the practical demonstrations (MRI,CT,US,PET), students are given a first introduction to the operation of the different imaging modalities used for biomedical imaging and research on animals and patients.   In the second part " Optical techniques" we discuss correctly use and types of optical microscopes. The rays and application possibilities of among other things the compound microscope, phase contrast microscope, dark field microscope, fluorescence microscope and confocal laser scanning microscope are treated. Lab demonstrations - under form of capita selecta - show some modern optical measure techniques which are used in medical imaging. 4. Teaching method Direct contact: Lectures Practical sessions Personal work: Assignments - individual 5. Assessment method Exam: Written, without oral presentation Oral, with written preparation Multiple choice Open questions Written assignment: Without oral presentation 6. Compulsory reading – study material Course documents An electronic version of the presentations can be downloaded from Blackboard. A print out of the presentations (2 hand-out/page) can be bought at the reprography of the University of Antwerp. 7. Recommended reading - study material Medical Imaging Physics, 4th ed. William R. Hendee, E. Russell Ritenour, ed. Wiley-Liss, 2002 , NY-ISBN 0-471-38226-4   Fundamentals of Medical Imaging, Paul Suetens Publisher: Cambridge University Press; Bk&CD-Rom edition (March 2002) ISBN: 0521803624   MRI From picture to proton, Donald W. McRobbie, Elizabeth A. Moore, Martin J. Graves, Martin R. Prince, Publisher: CambridgeUniversity Pres, ISBN 0-521-68384-X paperback   Radiobiology for the Radiologist, 6th ed. Eric J. Hall, Amato J. Giacca Lippincott Williams & Wilkins, 2006, ISBN 0781741513 8. Tutoring You can always ask the teacher questions after or during the pause of a contact moment.   Dr. Marleen Verhoye BioImagingLab University of Antwerp, Campus Groenenborger (CGB) Groenenborgerlaan, 171 B-2020 Antwerp Belgium Tel:       ++ 32 (0)3 2653389             ++ 32 (0)3 2653230  Fax.      ++ 32 (0)3 2653233 email: Marleen.Verhoye@ua.ac.be http://webhost.ua.ac.be/biomag/     laatste aanpassing: last update: 13/10/2010 13:54 marleen.verhoye