Principles of in vivo biomedical imaging, preclinical and clinical studies

Academic year: 2010-2011 Course code module 1MBMW-K-0192 Semester: 1st semester Credits: 6 Study load (hours) 168 Theory (hours): 25,00 Practice/Exercises(hours): 15,00 Other (hours): 15,00 Part-time program: 1 Instructor(s) Marleen Verhoye Johan Van Goethem Language of instruction: English Semester exam information: exam in the 1st semester Contract restriction information: exam contract not possible 1. Prerequisites *Algemene competenties The prerequisites of 'In-vivo biomedical imaging techniques in pre-clinical and clinical context' is closely connected to the objectives of the 'Physics' course (1st Ba). Physical variables/principles which were not discussed in the 'Physics' course context,  still which are rather necessary for a good understanding of the subject matter are considered within this course. The student must have a sufficient knowledge in basic mathematical (vectors, derivatives, simple goniometrical functions, algebra, equations, solving set of equations (classical methods); basic principles of calculus (differential and integral - secondary school). *Sequentiality None 2. Objectives (expected learning outcomes) What are you considered to know/anticipate by pursuing this course?   You have insight in the interaction of radiation with matter and patients; You have developed an insight in the physical principles of different imaging techniques and their practical use in modern imaging instrumentation; you are potentially able to describe these in your own words, recognize and formulate; you have developed an insight in the reconstruction of different image modalities and the physical parameter which is being visualized (eg. absorption, reflection, transmission, scattering, energy, radioactive decay, frequency shift, energy of nucleus in extern magnetic field, temperature,..); you are potentially able to describe these in your own words, recognize, formulate; for each of the discussed imaging techniques you are able to describe the origin of the image intensities; you are able to explain why specific tissues are represented dark or bright in the images; you have developed an insight how different imaging techniques can be used in a preclinical and a clinical context. 3. Course content The course discusses the physical principles, image reconstruction and clinical & preclinical applications of the different biomedical imaging modalities: interaction of radiation with matter X-ray imaging and CT-scan: instrumentation,  interaction of X-radiation with matter and patients, possibilities of imaging, image reconstruction, artifacts Echography with ultrasound: instrumentation, interaction US wave with matter, possibilities of imaging (A,B,M-mode-real time), Doppler ultrasound Magnetic Resonance Imaging: instrumentation, origin of the MR signal, image contrast, image reconstruction Radionuclide imaging: scintigraphy, SPECT and PET, radioactivity and detectors   During the practical demonstrations (MRI,CT,US,PET), students will be introduced to the operation of the different imaging modalities being used for biomedical imaging and research on laboratory animals and patients.   4. Teaching method Direct contact: Lectures Practical sessions Personal work: Assignments - individual Paper - individual 5. Assessment method Exam: Oral, with written preparation Multiple choice Open questions Written assignment: Without oral presentation 6. Compulsory reading – study material Course documents An electronic version of the presentations can be downloaded from Blackboard. A print out of the presentations (2 hand-out/page) can be bought at the reprography of the University of Antwerp.   websites 7. Recommended reading - study material Medical Imaging Physics, 4th ed. William R. Hendee, E. Russell Ritenour, ed. Wiley-Liss, 2002 , NY-ISBN 0-471-38226-4   Fundamentals of Medical Imaging, Paul Suetens Publisher: Cambridge University Press; Bk&CD-Rom edition (March 2002) ISBN: 0521803624   MRI From picture to proton, Donald W. McRobbie, Elizabeth A. Moore, Martin J. Graves , Martin R. Prince, Publisher: CambridgeUniversity Pres, ISBN 0-521-68384-X paperback   Radiobiology for the Radiologist, 6th ed. Eric J. Hall, Amato J. Giacca Lippincott Williams & Wilkins, 2006, ISBN 0781741513   Medical Imaging, Signals and Systems, Jerry L. Prionce, Jonathan M. Links, Pearson Edudaction, ISBN 0-13-065353-5   8. Tutoring You can always ask the teacher questions after or during the pause of a contact moment. laatste aanpassing: last update: 13/10/2010 13:54 marleen.verhoye